This optional main plot quest is available to you only if you recruited Isabela in Act 1 and follows immediately after Following The Qun. Stop by the Hawke Estate to barge in the middle of a quarrel between Aveline and Isabela. Isabela insists that the relic is somehow tied in with this growing animosity among the Qunari and so requests your help to mitigate the threat against her. If you refuse, Isabela will leave the party permanently. You will, however, end up losing the curvaceous vixen for a time regardless. Obviously, if she holds a special spot in your party, you'd want to postpone doing this quest for as long as possible and make sure you complete her Questioning Beliefs relationship quest.
March off to Lowtown at night to begin the quest apace. You find a group of brutish-looking Qunari waiting by the Lost-End Foundry entrance and assail the party after a few quick exchanges of words. Sort out the matter of the relic with Isabela after the battle. Give the relic to Isabela and receive a flood of approval from Isabela and fellow companions. The contrary happens if the relic is returned to the Qunari. You run into quite the tiff when you enter the Foundry. Isabela leaves to pursue the relic, leaving you to deal with a hodgepodge of Qunari and Tevinter enemies. Luckily, only a select few deserve your attention, namely the mage and the Qunari named Sten. With one man down, the battle can spin out of control without proper use of crowd control. Employing status effects is more useful more than ever when lacking Isabela's cannon-like firepower.
The quest marker points to the Foundry's exit, but take a brief moment to collect the loot from the upper rooms, including an armor upgrade for Isabela, Lambswoold Insoles.
Back outside, Isabela's handiwork is put on display -- loot Isabela's Letter from the poor bloke's lifeless body. At this point, Isabela has left your party for good unless you pursued her rigously on the romantic level.