MCAS Diet | Mast-Cell Activation Syndrome (2024)

Contents

What Is A Mast Cell Activation Syndrome diet?

How do you stabilise mast cells naturally?

How to calm a mast cell activation?

Which foods reduce histamine?

What can I eat with mast cell activation syndrome?

Medications to avoid with mast cell activation disorder

What medications can trigger mastocytosis?

Which drug suppresses the release of histamine from mast cells?

Which antihistamine is best for mast cell activation syndrome?

What Is A Mast Cell Activation Syndrome diet?

Mast cells are immune cells found in our blood that help defend against disease-causing pathogens and parasites. However, sometimes they go haywire and start to attack healthy tissue instead of pathogens. This leads to a host of issues – including inflammation, allergies, asthma, high blood pressure, heart disease, arthritis, and a host of others.

Mast Cell Activation Syndrome Diets are diets designed to reduce the response of mast cells but improving histamine balance. These diets may be recommended for people who suffer from symptoms of MCAS.

How do you stabilise mast cells naturally?

MCAS Diet | Mast-Cell Activation Syndrome (1)

There are a few ways to stabilise mast cells naturally. For example, you can take antihistamines or try to avoid irritants that increase the release of histamine.

The following are some methods to stabilise mast cells naturally:

  • The best way to stabilise mast cells is through the use of herbs. One of the best herbs that can be used to stabilise mast cells is the nettle root. This herb has been around for many centuries and is most commonly used to treat pain. This natural plant is also said to help with arthritis, eczema, gout, and anemia.
  • Take a supplement that contains chamomile, lemon balm, and wild oregano. They are known to help with stress, insomnia, and mood disorders such as anxiety.
  • Consuming fatty fish or salmon may help to prevent and fight allergies. Omega-3 fatty acids are an effective way of calming the release of histamine, which can lead to an improvement in symptoms for those who suffer from allergic reactions.
  • A cold compress can reduce the release of histamine to calm the symptoms associated with histamine release.
  • One way to stabilise mast cells is through the use of honey bee pollen. This natural substance has a rich history of being used to remedy many ailments, such as allergies, inflammation, and even asthma.
  • Avoiding stress can help to prevent mast cell problems. It is essential to take time away from situations that cause harm to your body – whether that means curtailing your work hours, exercising more, or doing something other than what causes you stress.
  • You can stabilise mast cells by having a healthy immune system. For this purpose, you can have a diet that is rich in proteins and minerals.

How to calm a mast cell activation?

  1. Avoid foods high in histamines such as leftover foods, alcohol, cured meats like bacon, ham, and canned fish.
  2. It is essential to avoid extreme temperatures, molds, medications that release histamine at high levels, and common preservatives like sodium benzoate.
  3. You need a healthy gut to take care of your overall health. You shouldn’t eat foods that cause inflammation or damage your gut, so you should take a probiotics supplement and a DAO enzyme when trying to do so.
  4. Quercetin and vitamin C can help to control the release of histamine.
  1. If you have any existing infections or if you’re overly stressed, talk to a doctor. They’ll be able to test for pathogens and help your body heal with appropriate treatments.
  2. You can reduce your exposure to toxins in your life by switching to natural cleaners and household products, or better yet, using a whole-food diet.
  3. Take the herbs nigella sativa, butterbur, turmeric, ginger, and peppermint to support your menstrual cycle and MCAS treatment.
  4. Your body’s cycles and daily activities are closely linked, so try to stick to a routine. This will also help you reduce the impact of MCAS on your life.

Which foods reduce histamine?

MCAS Diet | Mast-Cell Activation Syndrome (2)

Foods with anti-inflammatory properties help reduce the release of histamines. These food include asparagus, broccoli, cabbage, cucumbers, garlic, kale, leeks, onions, peppers, radishes and watercress. Ensuring the meat is fresh can also be key. This also included not eating reheated meats. Eg leftovers.

Food to avoid with mast cell activation syndrome?

Vegetables – Sauerkraut, spinach, tomatoes (including ketchup, tomato juice, etc.), eggplant, avocado, olives Legumes (lentils, beans, soy, soy products such as tofu)

Fruits – Strawberries, raspberries, lemons, oranges and other citrus fruits, banana, pineapple, kiwi, pears, papaya, guava.

What can I eat with mast cell activation syndrome?

For those with mast cell activation syndrome, food can be a challenge. Some foods will trigger an allergic reaction or pain in the throat that requires immediate attention.

Many people with mast cell activation syndrome have a reduced appetite and may have trouble eating. Some people also experience diarrhoea or stomach discomfort. This can be treated with medication or dietary changes.

Many fruits are well tolerated – these include apple, peach, apricot, melon, mango, persimmon, lychee, cherries, sour cherries, blackberries, blueberries, cranberries, currants, cassis, jostaberry, fresh, frozen or canned. As well as nuts such as macadamias and chestnuts.

You can eat vegetables like broccoli, cauliflower, carrots, garlic, and asparagus. Fresh meat can also be eaten safely when you have Mast Cell Activation Syndrome.

Medications to avoid with mast cell activation disorder

MCAS Diet | Mast-Cell Activation Syndrome (3)

Medications that cause mediator releases may best be avoided. These include aspirin, non-steroidal anti-inflammatory drugs, codeine, morphine, thiamine, quinine, nasal steroid sprays, antidepressants, and opiates. However, you should always consult with your doctor before making any changes to medications.

What medications can trigger mastocytosis?

A list of medications that can trigger mastocytosis:

1. Erythropoietin

2. Oral contraceptives

3. Thyroxine

4. Corticosteroids

5. Methotrexate

6. Azathioprine

7. Ciprofloxacin

Hormonal medications, such as progesterone or estrogen, can also trigger mastocytosis.

Moreover, anti-cancer medications can also cause mastocytosis. These include cyclophosphamide, doxorubicin, methotrexate, and platinum compounds.

Which drug suppresses the release of histamine from mast cells?

Diphenhydramine is the most common drug that suppresses the release of histamine from mast cells. Cromolyn sodium, Dimenhydrinate, and hydroxyzine are some other drugs that suppress the release of histamine from the mast cells.

Which antihistamine is best for mast cell activation syndrome?

It is unknown what causes mast cell activation syndrome, but it is believed to be related to histamine release. H1 blockers help decrease the amount of histamine in the body and therefore help decrease the severity of symptoms in mast cell activation syndrome.

Many antihistamines are available today and are becoming more popular with each generation. With the decrease in side effects as well, these types of drugs are favoured over the first-generation blockers. They can be helpful for chest pain and other GI symptoms.

When you have mast cell activation syndrome, an antihistamine may help with the symptoms. These include:

1) Benadryl

2) Claritin

3) Zyrtec

Does the gut impact histamine?

The main enzyme (DAO) used to break down histamine is present in the lining of the digestive tract and imbalance in the beneficial microbes may impact the bodies ability to process histamine, leading to accumulation.

Working to support balance of the gut microbiome is often a central area to address with histamine issues.

MCAS Diet | Mast-Cell Activation Syndrome (2024)

FAQs

What is the best diet for mast cell activation syndrome? ›

13,14 Although formal studies are lacking, the optimal diet for MCAS may be one containing whole foods with reduction of ultra-processed foods and avoidance of perceived triggers and intolerances including dairy products high in lactose, wheat and gluten-containing foods, and food preservatives and dyes.

How to stop mast cell activation naturally? ›

Natural antihistamines, such as quercetin and bromelain, have been found to inhibit mast cell activation and reduce histamine release. Additionally, supplements like vitamin C and omega-3 fatty acids have anti-inflammatory properties that can help alleviate symptoms associated with mast cell disorder.

How to heal your gut with MCAS? ›

Probiotics: Gut health is important for MCAS patients. Probiotics can help improve gut health by reducing inflammation and improving digestion. Environmental Modifications: Identifying and minimizing exposure to environmental triggers, such as mold or pollutants, is crucial.

How did I cured my mast cell activation? ›

There is currently no cure for mast cell disease. Treatment is aimed at reducing the occurrence of episodes and reducing the severity of symptoms.

What foods flush out histamine? ›

Foods which are reported as having lower histamine levels include most fresh produce, fresh meat, certain fresh/frozen fish, eggs including quail eggs and most fresh herbs.

What are the worst histamine foods? ›

Foods High in Histamine
  • High-Histamine Foods.
  • Processed Meats.
  • Aged Cheeses.
  • Alcohol.
  • Fermented Foods.
  • Fruits and Vegetables.
  • Legumes.
  • Spoiled Fish.

What is the root cause of MCAS? ›

In our clinical experience, mould exposure or sick building syndrome is at the root of 90% of MCAS cases.

What vitamin deficiency causes mast cell activation? ›

Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization.

What calms a MCAS flare? ›

Depending on your symptoms, your provider might prescribe: Histamine type 1 receptor blockers (antihistamines). These can treat allergy symptoms and include loratadine, cetirizine and fexofenadine. Histamine type 2 receptor blockers (antihistamines that reduce stomach acid).

Is fasting good for MCAS? ›

A study suggested starving the mast cells (fasting for 3-4 days) with only bone broth. This would reboot the body and generate new cells. It only lasts about 4-6 months and then you would have to do it again to continue a type of remission.

Can MCAS go into remission? ›

Patients with MCAS may go through periods of remission followed by a flare-up of symptoms. Over time, symptom-free intervals shorten and eventually your symptoms become chronic with fluctuating levels of intensity. Over time, the type of symptoms you are experiencing may also vary.

Does B12 stabilize mast cells? ›

The findings indicate that by stabilizing mast cells and helping to block the release of histamine, vitamin B12 can help protect against inflammation-induced skin barrier damage and relieve skin sensitivity and irritations cause by environmental stress factors.

What is the best diet for MCAS? ›

Many people with MCAS find certain diets helpful for managing their symptoms. For example, low histamine, gluten free, lactose free, low oxalate or low amine diets.

What is the new treatment for MCAS? ›

Recent findings: Tyrosine-kinase inhibitors (TKIs) targeting wild-type and mutated KIT can efficiently induce MC depletion. Avapritinib and midostaurin can also temper IgE-mediated degranulation. Avapritinib has been recently approved by the FDA for the treatment of indolent systemic mastocytosis (ISM).

What are the symptoms of MCAS in the eyes? ›

MCAS can affect many body systems:

Eyes/Ears: dry, itching or burning eyes, conjunctivitis, watery eyes, visual disturbance, ringing in the ears, hypersensitivity to light or sound.

Is coffee good for MCAS? ›

Coffee has been shown to have numerous health benefits, many of which could potentially help those with MCAS: Coffee has significant levels of polyphenols such as chlorogenic acids (CGA), which exert a variety of positive biological effects, including anti-inflammatory and anti-bacterial properties.

What is the root cause of mast cell activation syndrome? ›

Primary disorders of mast cell activation usually happen when there's a problem with the mast cell or its parent cells, which causes extra production of mast cells. This problem may occur when there is a mutation in a gene called KIT.

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