Side effects of nifedipine (2024)

Common side effects

These common side effects of nifedipine happen in more than 1 in 100 people. There are things you can do to help cope with them:

Headaches

Make sure you rest and drink plenty of fluids. Try not to drink too much alcohol. Ask your pharmacist to recommend a painkiller. Paracetamol is safe to take with nifedipine.

Headaches should usually go away after the first week of taking nifedipine. Talk to your doctor if they last longer than a week or are severe.

Feeling dizzy

If nifedipine makes you feel dizzy, stop what you're doing and sit or lie down until you feel better. Do not drive, ride a bike or operate tools or machinery until the dizziness passes. Speak to a doctor if the dizzy feelings last for more than a couple of days.

Flushing

This usually happens when you first start taking nifedipine. Try cutting down on coffee, tea and alcohol. If the flushing is also making you feel hot, it might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks.

The flushing should go away after a few days, so try to carry on taking nifedipine for this time. If it does not go away or is causing you problems, contact your doctor.

A fast, pounding or irregular heartbeat (palpitations)

If this happens regularly after you take your medicine, try to take it at a time when you can sit or lie down while the symptoms are at their worst. It might also help to cut down on alcohol, smoking, caffeine and big meals as these can make the problem worse.

If you have a history of heart disease, and you are having these symptoms for a long time, these symptoms do not improve, or you are concerned, speak to your doctor.

Swollen legs or ankles (oedema)

Try raising your legs when you're sitting down.

Constipation

Eat plenty of high-fibre foods such as fresh fruit and vegetables and cereals, and drink lots of water. Try to exercise regularly, for example by going for a daily walk or run. It's OK to occasionally use a laxative.

Speak to a doctor or pharmacist if the advice on how to cope does not help and a side effect is still bothering you or lasts more than a few days.

Serious side effects

Serious side effects after taking nifedipine are rare and happen in less than 1 in 1,000 people.

Stop taking nifedipine and call 111 straight away if the whites of your eyes turn yellow, or your skin turns yellow although this may be less obvious on brown or black skin. These can be signs of liver problems.

Immediate action required: Call 999 now if:

  • you get chest pain that does not stop after a few minutes, or is new or worse if you already have angina

Chest pain is a possible sign of a heart attack and needs to be checked as soon as possible.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to nifedipine.

Immediate action required: Call 999 now if:

  • your lips, mouth, throat or tongue suddenly become swollen
  • you're breathing very fast or struggling to breathe (you may become very wheezy or feel like you're choking or gasping for air)
  • your throat feels tight or you're struggling to swallow
  • your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • you suddenly become very confused, drowsy or dizzy
  • someone faints and cannot be woken up
  • a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Information:

Do not drive yourself to A&E.

The person you speak to at 999 will give you advice about what to do.

Other side effects

These are not all the side effects of nifedipine. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Side effects of nifedipine (2024)

FAQs

What is the most common side effect of nifedipine? ›

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. These symptoms are more likely to occur when you begin taking this medicine, or when the dose is increased. This medicine may cause fluid retention (edema) in some patients.

How do you counteract the side effects of nifedipine? ›

Try cutting down on coffee, tea and alcohol. If the flushing is also making you feel hot, it might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks. The flushing should go away after a few days, so try to carry on taking nifedipine for this time.

Why is nifedipine not recommended? ›

Nifedipine can exacerbate hypoperfusion to vital organs in patients with severe hypotension. [13] Furthermore, patients with hepatic impairment may not be able to metabolize nifedipine, leading to a longer half-life, putting them at an increased risk of toxicity and side effects.

What vitamins should not be taken with nifedipine? ›

Interactions with Nifedipine
  • Calcium.
  • Coenzyme Q10.
  • Ephedra.
  • Magnesium.
  • Melatonin.
  • Vitamin D.

What are the two worst blood pressure medications? ›

5 of the worst blood pressure medications
  1. Beta blockers. Usually, beta blockers aren't used as first-choice therapies to lower blood pressure. ...
  2. Loop diuretics. Furosemide (Lasix) is a type of diuretic (water pill) known as a loop diuretic. ...
  3. Alpha blockers. ...
  4. Vasodilators. ...
  5. Alpha-2 agonists.

Who cannot take nifedipine? ›

have ever had an allergic reaction to nifedipine or any other medicine. have liver disease. have any heart problems (other than high blood pressure), including a recent heart attack, heart failure or unstable angina. have diabetes.

What not to mix with nifedipine? ›

You should not use this medicine if you are also taking certain other medications such as carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), or St. John's Wort. Using these medicines together can cause serious problems.

When will nifedipine side effects go away? ›

How long do nifedipine side effects last? Most common side effects and some serious side effects resolve on their own within several days to weeks of stopping or changing the dose of the medication.

What is a good replacement for nifedipine? ›

Nisoldipine appears to be an effective substitute treatment for nifedipine in severely hypertensive patients sensitive or resistant to nifedipine.

Which is safer amlodipine or nifedipine? ›

Amlodipine and nifedipine have similar antihypertensive effects; amlodipine appeared to be better tolerated.

Why is nifedipine no longer available? ›

Because of several reports of serious adverse reactions occurring after the administration of immediate-release nifedipine, the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure has discouraged the use of this drug.

Is nifedipine a high risk medication? ›

Nifedipine may increase your risk of heart failure. Tell your healthcare provider right away if you have any of the following symptoms of heart failure. Stomach Obstruction or Ulcers. In rare cases, stomach obstruction or ulcers have occurred in people taking nifedipine extended-release tablets.

What happens when you take vitamin D with nifedipine? ›

Interactions between your drugs

No interactions were found between nifedipine and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can you eat bananas on blood pressure medication? ›

Can you eat bananas while on blood pressure medication? Unless you have kidney disease or kidney problems or have been advised by a medical provider to avoid them, you can eat bananas while you take losartan or other blood pressure medication. Always check with your doctor if you have any questions or concerns.

Is nifedipine hard on the kidneys? ›

Previous studies reported that nifedipine can lead to AKI by causing deleterious kidney hemodynamic alterations [9].

What should you avoid taking nifedipine? ›

Grapefruits and grapefruit juice may increase the effects of nifedipine by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you taking this medicine. Do not take other medicines unless they have been discussed with your doctor.

Should I take nifedipine in the morning or at night? ›

Nifedipine is very sensitive to light, so make sure you take your tablet or capsule as soon as you take it out of the packet. You can take nifedipine at any time of day, but try to make sure it's around the same time (or times) every day. Swallow the capsules or tablets whole with a drink of water.

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