Myf5 myogenic factor 5 [Mus musculus (house mouse)] - Gene (2024)

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What is the function of Myf5? ›

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs).

Muscle progenitor cells differentiate into myoblasts that express the MRFs. MyoD (Mvodl) and Myf5. Proliferating myoblasts withdraw from the cell cycle to become terminally differentiated myocytes that express muscle-specific genes such as myogenin (Myog).

In subject area: Pharmacology, Toxicology and Pharmaceutical Science. Myogenic regulatory factors are a group of transcription factors that induce the transcription of skeletal muscle proteins and coordinate satellite cell differentiation.

Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair.

Myogenesis: The Development of Muscle - Developmental Biology - NCBI Bookshelf. The .

The term holin was coined to denote proteins that form lethal and non-specific holes in the IM. As established in coliphage systems, the holin has two roles, serving to release the endolysin into the periplasm as well as to function as the “lysis clock”.

Myogenic activity refers to the ability of a muscle to contract reflexively without nervous stimulation. Smooth and cardiac muscle both possess myogenic activity. Both the muscles are involuntary muscles. Skeletal muscles are closely associated with skeletal components in the human body.

Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues | Modern Pathology.

MyoD plays an important role in determining diaphragmatic contractile properties. MyoD recruits cdk9/cyclin T2, together with the histone acetyltransferases p300 and PCAF, and the chromatin remodeling complex SWI/SNF, on promoters and enhancers of muscle-specific genes.

Myogenic conditions may involve individual extraocular muscles or a combination and are often bilateral conditions. Thyroid eye disease. The wet phase of the thyroid ocular condition is a myogenic disorder that often progresses to a mechanical condition.

What does myogenic mean in medical terms? ›

adjective. myo·​gen·​ic ˌmī-ə-ˈje-nik. : taking place or functioning in ordered rhythmic fashion because of the inherent properties of cardiac muscle rather than specific neural stimuli. a myogenic heartbeat.

Since the heartbeat is initiated by the SA node and the impulse of contraction originates in the heart itself, the human heart is termed myogenic. The hearts of vertebrates and molluscs are also myogenic.

MyoD translocates to the nucleus to act as a transcription factor and also physically interacts with CDK4 to inhibit cell proliferation by inducing cell cycle arrest. (3) MyoD heterodimerizes with E-proteins to directly transactivate genes required to initiate myogenic differentiation, such as myogenin.

MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. HBXIP up-regulates YAP expression via activating transcription factor c-Myb to facilitate the growth of hepatoma cells. c-myb overexpression is associated with Breast Cancer Invasion and Metastasis.

Mutation frequency decline (Mfd) is a bacterial ATP-dependent DNA translocase that couples DNA repair to transcription via hydrolyzing ATP as energy, which preferentially acts on the damaged DNA transcribed strand to rescue stalled RNAP or dissociate RNAP to terminate the transcription depending on impediment severity, ...

Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions.

Neuroligin 1 is a protein that contains a cholinesterase-like domain and is involved in synaptic localization through binding with neurexin. It has glycosylation sites in its extracellular region and plays a role in regulating synaptic connections.

The roles that perlecan may play are vast. For example, perlecan is involved in regulating skin and endochondral bone formation [127,148], modulation of lipid metabolism [149], cell adhesion and cell death [150–152], and osteophyte formation [153].

The WUSCHEL (WUS) protein plays a central role in the maintenance of stem cell populations in shoot and floral meristems (Laux et al., 1996; Mayer et al., 1998; Veit, 2004). WUS positively regulates the size of each shoot meristem by maintaining the appropriate number of pluripotent stem cells in each shoot meristem.