How and when to take nifedipine (2024)

Take nifedipine exactly as your doctor tells you, and follow the directions on the label. If you're not sure, check with your doctor or pharmacist.

Nifedipine comes as standard capsules, or more commonly as slow-release tablets or capsules. These often have letters (XL, LA, SR, MR) or "Retard" after the brand name.

Slow-release tablets and capsules release the medicine into your body gradually throughout the day. This usually means you do not need to take them as often.

Dosage and strength

Nifedipine comes as:

  • 5mg and 10mg standard capsules
  • 10mg, 20mg, 30mg, 40mg and 60mg slow-release tablets and capsules

Your dose of nifedipine depends on why you need the medicine and what kind your doctor has prescribed.

To decide the correct dose for you, your doctor will check your blood pressure. The usual starting dose is:

  • standard capsules or liquid – 5mg, taken 3 times a day (every 8 hours)
  • slow-release tablets or capsules – 10mg, taken twice a day (every 12 hours), or 20 to 30mg, taken once a day (every 24 hours, preferably in the morning)

If a doctor prescribes it for your child, the dose will usually be lower. It will depend on how old your child is and how much they weigh.

How to take it

Nifedipine is very sensitive to light, so make sure you take your tablet or capsule as soon as you take it out of the packet.

You can take nifedipine at any time of day, but try to make sure it's around the same time (or times) every day.

Swallow the capsules or tablets whole with a drink of water. Do not break, crush, chew or open up the capsules unless your doctor or pharmacist has said you can.

It usually does not matter if you take nifedipine with or without food, but check the leaflet of the brand you're taking because the advice can vary.

There are several brands of slow-release nifedipine, which may not all be the same. Make sure you stick to the same brand if possible and follow the directions on how to take it carefully.

With some of the slow-release tablets, you might notice what looks like a whole tablet in your poo. Do not worry, this is normal. It's just the outer shell of the tablet which your body has not digested.

If you're taking nifedipine as a liquid, shake the bottle well. The medicine will come with a plastic syringe or spoon to help you take the right amount. If you do not have a plastic syringe or spoon, ask your pharmacist for one. Do not use a kitchen teaspoon as it will not measure the right amount.

Important

Take nifedipine even if you feel well, as you will still be getting the benefits of the medicine.

How long to take it for

Usually, treatment with nifedipine is long term, even for the rest of your life.

Changing your dose

If the starting dose is not working well enough (your blood pressure does not come down enough, or you are still getting symptoms), you may need to increase your dose. If you're bothered by side effects, you may need to stay on a lower dose.

The usual maximum doses of nifedipine are:

  • standard capsules or liquid – 20mg, taken 3 times a day (total of 60mg a day)
  • slow-release capsules or tablets – 40mg, taken twice a day, or 90mg once a day (total of 80mg or 90mg a day)

If you forget to take it

If you forget to take a dose and you usually take nifedipine:

  • 3 times a day – leave out that dose and take your next dose at the usual time
  • twice a day – take it as soon as you remember unless it is less than 4 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time
  • once a day – take it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time

Never take 2 doses to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

If you take too much

The amount of nifedipine that can lead to an overdose varies from person to person.

Taking too much nifedipine can make you feel:

  • dizzy
  • like your heart is not beating normally (irregular heartbeats)
  • sick (nausea)
  • confused
  • sleepy

Urgent advice: Contact 111 for advice now if:

  • you take more than your prescribed dose of nifedipine

Go to 111.nhs.uk or call 111

If you go to , do not drive yourself. Get someone else to drive you or call for an ambulance.

Take the nifedipine packet or leaflet inside it plus any remaining medicine with you.

Stopping taking nifedipine

Talk to your doctor if you want to stop taking nifedipine. Stopping may cause your blood pressure to go up, and this may increase your risk of heart attack and stroke.

If you're bothered by any side effects, your doctor may be able to prescribe you a different medicine.

How and when to take nifedipine (2024)

FAQs

How and when to take nifedipine? ›

standard capsules or liquid – 5mg, taken 3 times a day (every 8 hours) slow-release tablets or capsules – 10mg, taken twice a day (every 12 hours), or 20 to 30mg, taken once a day (every 24 hours, preferably in the morning)

What happens if I take nifedipine with food? ›

A study found that nifedipine reaches a maximum concentration much sooner in your body when you take it with food. Taking nifedipine on an empty stomach may help you maintain a more consistent level of the drug in your body. Talk with your healthcare provider about the best way for you to take nifedipine.

Does nifedipine have to be taken on an empty stomach? ›

Do not break, crush, or chew it. It is best to take this tablet on an empty stomach. If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

What should you avoid when taking nifedipine? ›

Is there any food or drink I need to avoid? Do not eat grapefruit or drink grapefruit juice. This is because grapefruit can increase the amount of nifedipine in your body, and cause side effects such as headache, flushing and feeling dizzy or faint.

How many hours does nifedipine stay in your system? ›

Some experts believe that Nifedipine stays in the system for seven hours. After you stop the medicine, traces are still present in urine and feces. Do not stop Nifedipine (as it may increase your blood pressure and the risk of a stroke and heart attack) unless your doctor suggests otherwise.

When is the best time to take nifedipine blood pressure medication? ›

You can take nifedipine at any time of day, but try to make sure it's around the same time (or times) every day. Swallow the capsules or tablets whole with a drink of water. Do not break, crush, chew or open up the capsules unless your doctor or pharmacist has said you can.

Can I drink coffee before taking nifedipine? ›

"° If caffeine interferes with the cardiovas- cular effects of nifedipine, it is conceivable that pre- treatment with caffeine could attenuate the blood pres- sure and heart rate responses to nifedipine. Conversely, nifedipine might not completely reverse the pressor re- sponse to caffeine.

What vitamins should not be taken with nifedipine? ›

Interactions with Nifedipine
  • Calcium.
  • Coenzyme Q10.
  • Ephedra.
  • Magnesium.
  • Melatonin.
  • Vitamin D.

Can nifedipine lower blood pressure immediately? ›

Nifedipine was successful in reducing diastolic blood pressure in 83% of the patients within 45 minutes and in 96% of the patients within two hours, with a mean reduction in systolic blood pressure of 47 mm Hg and diastolic blood pressure of 29 mm Hg.

Why is nifedipine no longer used? ›

Nifedipine, a dihydropyridine calcium channel blocker, was once one of the most widely used medications for hypertension, but safety and tolerability concerns along with the introduction of new classes of antihypertensive medications and an increasing pool of data showing mortality benefit of other classes caused ...

What are the two worst blood pressure medications? ›

5 of the worst blood pressure medications
  1. Beta blockers. Usually, beta blockers aren't used as first-choice therapies to lower blood pressure. ...
  2. Loop diuretics. Furosemide (Lasix) is a type of diuretic (water pill) known as a loop diuretic. ...
  3. Alpha blockers. ...
  4. Vasodilators. ...
  5. Alpha-2 agonists.

What is the most common side effect of nifedipine? ›

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. These symptoms are more likely to occur when you begin taking this medicine, or when the dose is increased. This medicine may cause fluid retention (edema) in some patients.

Is nifedipine hard on the kidneys? ›

Previous studies reported that nifedipine can lead to AKI by causing deleterious kidney hemodynamic alterations [9].

Why is nifedipine taken at night? ›

Bedtime dosing of nifedipine GITS was significantly more efficient than morning dosing in reducing night time BP (Figure 2). On the other hand, nifedipine at bedtime was also highly efficient in reducing the morning BP surge, an independent predictor of stroke.

What is a good replacement for nifedipine? ›

Nisoldipine appears to be an effective substitute treatment for nifedipine in severely hypertensive patients sensitive or resistant to nifedipine.

Who cannot take nifedipine? ›

have ever had an allergic reaction to nifedipine or any other medicine. have liver disease. have any heart problems (other than high blood pressure), including a recent heart attack, heart failure or unstable angina. have diabetes.

Can I take nifedipine while fasting? ›

Once daily dosing of Adalat CC under fasting conditions results in decreased fluctuations in the plasma concentration of nifedipine when compared to t.i.d. dosing with immediate release nifedipine capsules.

Does nifedipine upset your stomach? ›

Shakiness. Severe constipation or stomach pain. These may be signs of a severe bowel problem. Black, tarry, or bloody stools.

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