Chymopapain (Injection Route) Description and Brand Names (2024)

FAQs

What is the route of injection of chymopapain? ›

The enzyme chymopapain is injected by the lateral route into the center of the nucleus with digestion of the proteoglycan of the nucleus and the herniation, the products being excreted in the urine.

Unfortunately, due to technical errors by some practitioners, chymopapain was injected into the subarachnoid space of a number of patients who developed severe neurological deficits, leading it to be removed from the US market in 1985, although it continued to be available in other parts of the world.

Chymopapain is injected directly into a herniated ("slipped'') disk in the spine to dissolve part of the disk and relieve the pain and other problems caused by the disk pressing on a nerve.

Chymopapain was first isolated in 1941 from the crude latex derived from the fruit of Carica papaya by squeezing the green papaya while on the plant prior to harvest. ⁶It is an extracellular plant cysteine proteinase similar to papain in specificity.

Administration by injection (parenteral administration) includes the following routes: Subcutaneous (under the skin) Intramuscular (in a muscle) Intravenous (in a vein)

Injection routes

Intramuscular (in a muscle) Intravenous (in a vein)

Very rarely, use of chymopapain may cause serious side effects, including paralysis of the legs or death. Another dangerous side effect of chymopapain injection is a severe allergic reaction called anaphylaxis.

Papayas contain two enzymes, papain and chymopapain. Both enzymes digest proteins, meaning they can help with digestion and reduce inflammation. Papain is an ingredient in some over-the-counter supplements to help with minor upset stomach. Both papain and chymopapain also help reduce inflammation.

The FDA rates ADR to have a more than 90% success rate, unlike spinal fusion surgery (which only has an approximate 70-90% success rate).

An epidural anesthesia injection works by injecting an anesthetic into the epidural space around your spine so that it can stop pain signals from traveling from your spine to your brain. The epidural space is filled with fluid and surrounds your spinal cord.

What is the injection in the spine to relieve pain? ›

An epidural steroid injection (ESI) is the delivery of powerful anti-inflammatory medicine directly into the space outside of the sac of fluid around your spinal cord. This area is called the epidural space. ESI is not the same as epidural anesthesia given just before childbirth or certain types of surgery.

Clip Injection is used to treat bleeding. It helps to prevent or reduce bleeding in conditions like tooth removal, heavy periods, dysfunctional uterine bleeding, nosebleed, and in any oral, prostate, or bladder surgery.

Viscoelastic Hyaluronate Injections

This acts as a lubricant and shock absorber to facilitate movement and reduce pain and inflammation.

What is Hernicore®? This is a treatment in which an enzyme(Condoliase)-containing drug (Hernicore®) is injected directly into the intervertebral disc to shrink the nucleus pulposus of the disc, the source of the herniation, thereby reducing the pressure on the nerves.

In the early 1960s he found that injections of papain, a simple papaya extract, dissolved the nuclei of discs between the vertebrae of rabbits. As a result, the discs shrank. If papain had the same effect on human slipped discs, he reasoned, they would shrink back into place.

Patients can administer calcitonin through a nasal spray or SQ or IM injection. All these formulations are rapidly absorbed in the body and exhibit an onset of action within less than 30 minutes.

Intramuscular injections will usually be given in the upper, outer part of the buttocks. In some cases, your healthcare provider may advise you on other areas to inject. Make sure you palpate (gently feel) your muscles before choosing a site.

Generally, hCG injections are given intramuscularly, and are directed toward the buttock or the deltoid muscles. However, in obese patients the needle may not be long enough to reach the muscle layer, especially when the subcutaneous fat is thick, and consequently the intended i.m. injection becomes a s.c. injection.

Grasp 4-5 inches of the muscle between your thumb and first finger. Inject the hormone by inserting the needle at a 90 degree angle, and pushing the plunger. FOR SUBCUTANEOUS INJECTIONS: The most common locations for injections in the fat is the stomach and the outer thigh.